SLE患者に発症したclomipramine hydrochloride によるpure red cell aplasia  [in Japanese] Pure red cell aplasia induced by clomipramine hydrochloride in a patient with SLE  [in Japanese]

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Author(s)

    • 古川 勝久 KOGAWA Katsuhisa
    • 札幌医科大学医学部第四内科 Department of Internal Medicine (Section 4), Sapporo Medical University School of Medicine
    • 佐藤 康史 SATO Yasushi
    • 札幌医科大学医学部第四内科 Department of Internal Medicine (Section 4), Sapporo Medical University School of Medicine
    • 信岡 純 NOBUOKA Atsushi
    • 札幌医科大学医学部第四内科 Department of Internal Medicine (Section 4), Sapporo Medical University School of Medicine
    • 井山 諭 IYAMA Satoshi
    • 札幌医科大学医学部第四内科 Department of Internal Medicine (Section 4), Sapporo Medical University School of Medicine
    • 高田 弘一 TAKADA Kouichi
    • 札幌医科大学医学部第四内科 Department of Internal Medicine (Section 4), Sapporo Medical University School of Medicine
    • 萩原 誠也 HAGIWARA Seiya
    • 札幌医科大学医学部第四内科 Department of Internal Medicine (Section 4), Sapporo Medical University School of Medicine
    • 高橋 祥 TAKAHASHI Shou
    • 札幌医科大学医学部第四内科 Department of Internal Medicine (Section 4), Sapporo Medical University School of Medicine
    • 加藤 淳二 KATO Junji
    • 札幌医科大学医学部第四内科 Department of Internal Medicine (Section 4), Sapporo Medical University School of Medicine
    • 坂牧 純夫 SAKAMAKI Sumio
    • 札幌医科大学医学部第四内科 Department of Internal Medicine (Section 4), Sapporo Medical University School of Medicine

Abstract

症例はsystemic lupus erythematosus (SLE)に罹患している48歳の女性。clomipramine hydrochlorideの内服を開始した後に正球性正色素性貧血が出現した。網状赤血球は低値で,骨髄穿刺は選択的な赤芽球低形成を呈したため,pure red cell aplasia (PRCA)と診断した。貧血は同薬剤の中止によって改善した。いくつかの薬剤がPRCAの原因として知られているが,clomipramine hydrochlorideの報告はない。また,SLEを基礎疾患に有していたことは,薬剤性PRCAの発症機序として免疫異常を示唆していると考え報告する。

A 48-year-old woman, who had been suffering from systemic lupus erythematosus (SLE), developed normochromic normocytic anemia after receiving clomipramine hydrochloride. Her reticulocyte count was low, and a bone marrow aspirate revealed erythroid hypoplasia without involvement of other cell lines. Thus a diagnosis of pure red cell aplasia (PRCA) was made. The anemia gradually resolved following withdrawal of the drug. Although several drugs are known to cause PRCA, this is the first time that clomipramine hydrochloride has been reported to have such an effect. The underlying SLE in this case suggested the possible immunological pathogenesis of drug-induced PRCA.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 41(8), 648-652, 2000-08-30

    The Japanese Society of Hematology

References:  14

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008038065
  • NII NACSIS-CAT ID (NCID)
    AN00252940
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    04851439
  • NDL Article ID
    6295721
  • NDL Source Classification
    ZS21(科学技術--医学--内科学)
  • NDL Call No.
    Z19-295
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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