Nonepisodic angioedema with eosinophiliaの5症例  [in Japanese] Five cases of nonepisodic angioedema with eosinophilia  [in Japanese]

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Abstract

Gleichらが報告した好酸球性血管性浮腫(EAE)は,再発性の血管性浮腫,蕁麻疹,発熱,体重増加,好酸球増加等の特徴を示す原因不明の疾患である。好酸球増加(4,900∼10,400/μ<i>l</i>)で紹介された5症例(23歳から32歳の女性)を経験した。主訴は蕁麻疹を伴わない下肢の浮腫と痛みで,発熱,体重増加もほとんど認めなかった。無治療で経過観察したところ全例が3カ月以内に軽快し,再発していない。これらの特徴はChikamaらが本邦に多いと報告したEAEのnonepisodic type (NEAE)に一致した。さらに自験例と25例の既報告本邦症例をあわせて検討した結果,すでに報告されたNEAEの特徴に加えて,1) 秋に好発する傾向を認める,2) 皮疹を伴わず,関節痛を伴う症例を認める,3) 一部にLDHの増加を認めることを指摘した。NEAEは自然軽快することが多いので,無治療で経過観察するか抗アレルギー薬の使用を第一選択とすることが可能と考える。

The syndrome of episodic angioedema associated with eosinophilia (EAE), originally identified by Gleich et al., is characterized by recurrent attacks of angioedema, urticaria, fever, increased body weight, and eosinophilia of unknown origin. Five young (aged 23∼32 years) female patients were referred to our hospital because of eosinophilia (4,900∼10,400/μ<i>l</i>). The chief complaints in all patients were angioedema and pain in the lower extremities without urticaria. Fever and increased body weight were not evident in most of the patients. These clinical features resolved spontaneously within 3 months, and no recurrence was observed. These characteristics were consistent with nonepisodic-type EAE (NEAE), which was proposed by Chikama et al. and is observed frequently in Japan. The clinical characteristics of NEAE were studied in the present 5 cases and the 25 cases reported previously in Japan. This revealed some additional characteristics: 1) a tendency for occurrence in autumn, 2) arthritis and absence of urticaria in some patients, and 3) increased serum LDH levels in some cases. It is suggested that NEAE should be treated with antiallergic drugs or simply followed without treatment, because spontaneous remission is observed frequently.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 42(8), 639-643, 2001-08-30

    The Japanese Society of Hematology

References:  15

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008038409
  • NII NACSIS-CAT ID (NCID)
    AN00252940
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    04851439
  • NDL Article ID
    6293937
  • NDL Source Classification
    ZS21(科学技術--医学--内科学)
  • NDL Call No.
    Z19-295
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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