Artificial Insemination Using the Husband's Frozen Sperm in a Patient with Chronic Myelogenous Leukemia After Bone Marrow Transplantation

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  • WATANABE Hiroshi
    Third Department of Internal Medicine, The Jikei University School of Medicine
  • ASAI Osamu
    Third Department of Internal Medicine, The Jikei University School of Medicine
  • TADA Norimichi
    Third Department of Internal Medicine, The Jikei University School of Medicine
  • YANO Shingo
    Third Department of Internal Medicine, The Jikei University School of Medicine
  • KATOH Akinori
    Third Department of Internal Medicine, The Jikei University School of Medicine
  • UNO Shinji
    Third Department of Internal Medicine, The Jikei University School of Medicine
  • OHSAWA Hiroshi
    Third Department of Internal Medicine, The Jikei University School of Medicine
  • UNOZAWA Toshio
    Third Department of Internal Medicine, The Jikei University School of Medicine
  • FUJII Tsunehiro
    Third Department of Internal Medicine, The Jikei University School of Medicine
  • NAKAMURA Tadashi
    Third Department of Internal Medicine, The Jikei University School of Medicine
  • KOBAYASHI Tadashi
    Third Department of Internal Medicine, The Jikei University School of Medicine
  • KURAISHI Yasunobu
    Third Department of Internal Medicine, The Jikei University School of Medicine
  • ISOGAI Yukihide
    Third Department of Internal Medicine, The Jikei University School of Medicine
  • KUSUHARA Kohji
    Department of Obstetrics and Gynecology, The Jikei University School of Medicine

Bibliographic Information

Other Title
  • 凍結保存精子による人工受精にて生児を得た同種骨髄移植後慢性骨髄性白血病の1例

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Abstract

A 37-year-old man with chronic myelogenous leukemia (CML) was scheduled to receive a bone marrow allograft from an HLA-matching sibling. He was married without children, and desired to have a child in the future. Sperm was collected before transplantation and frozen for preservation. Induction therapy performed using 8 mg/kg of busulfan, 120mg/kg of cyclophosphamide, splenic irradiation (4.5Gy), and total body irradiation (10Gy), and then allogenic bone marrow transplantation (BMT) was carried out. His post-transplantation course was uneventful and cyclosporin therapy was finished on day 187. The Philadelphia chromosome disappeared on day 20 after BMT and PCR analysis was negative for the bcr/abl rearrangement, suggesting the possibility of cure. Accordingly, artificial insemination was attempted using the frozen sperm. His wife became pregnant after the 4th attempt and a healthy baby was delivered. Transplantation recipients often become sterile because they receive ultra-high doses of chemotherapy and irradiation. However, it is still possible to have children if sperm or ova are preserved prior to transplantation. This is thought to improve the quality of life after BMT.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 36 (1), 35-39, 1995

    The Japanese Society of Hematology

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