Unclassified Chronic Myeloproliferative Disorder (Ph negative/bcr rearrangement negative CML) with Late Appearing Philadelphia like Chromosome

• HAMADA Kyoko

  Central Laboratory, Kochi Municipal Central Hospital

• TAKAHASHI Isao

  Department of Internal Medicine, Kochi Municipal Central Hospital

• SAIKA Tomoko

  Central Laboratory, Kochi Municipal Central Hospital

• KOMATSU Mariko

  Central Laboratory, Kochi Municipal Central Hospital

• YORIMITSU Seiichi

  Department of Internal Medicine, Kochi Municipal Central Hospital

• URATA Tomoyuki

  Department of Internal Medicine, Kochi Medical School

• SUNAMI Kazutaka

  Department of Internal Medicine, Okayama University Medical School

Bibliographic Information

Other Title

• 晩発性フィラデルフィア様染色体を認めた分類不能型骨髄増殖性疾患

Abstract

A 48-year-old male was diagnosed to be unclassified chronic myeloproliferative disorder (UCMPD)/Ph negative bcr rearrangement negative (Ph^-/bcr^-) CML by hematological, cytogenetical and DNA analyses (Jpn. J. Clin. Hematol. 33 (4): 525∼531, 1992). Three years and a half after the diagnosis of UCMPD/Ph^-bcr^- CML, Ph chromosome was observed in 17 of 20 examined cells. Hematological findings showed a transformation into blast crisis. The late appearing of Ph in a case of UCMPD/Ph^1-bcr^- CML described here is rare. Southern blot analysis using 3' and 5' bcr probe showed no bcr rearrangement. Analyses of BCR/ABL chimeric RNA by RT-PCR method were negative in both of Major-and Minor BCR/ABL chimeric RNA. In the present case it is speculated that Ph is developed as the result of multistep progeression and also speculated that the breakpoint at BCR gene differs from Major^- and Minor^-bcr in usual Ph⁺CML and de nove Ph⁺ ALL. Therefore, it may be reasonable that the present case is understood to be a case with late appearing Ph-like chromosome.

Journal

• Rinsho Ketsueki

  Rinsho Ketsueki 37 (3), 221-227, 1996

  The Japanese Society of Hematology

Keywords

• late-appearing Ph
• Ph^-/bcr^-CML
• unclassified myeloproliferative disorder

Details

• CRID: 1390282680004519808
• NII Article ID: 130004500252
• NII Article ID: 10008039044
• NII Book ID: AN00252940
• DOI: 10.11406/rinketsu.37.221
• COI: 1:STN:280:DyaK283ps12gsA%3D%3D
• ISSN: 18820824
• ISSN: 04851439
• PubMed: 8727346
• Web Site: https://search.jamas.or.jp/link/ui/1996194881
• Text Lang: ja
• Data Source:
  • JaLC
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed