Analysis of Behaviors of Plasma Tissue Factor and Tissue Factor Pathway Inhibitor in Patients with Various Diseases

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  • SAITO Masanori
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • MORISHITA Eriko
    Department of Laboratory of Medicine, Kanazawa University School of Medicine
  • ASAKURA Hidesaku
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • JOKAJI Hiroshi
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • UOTANI Chika
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • KUMABASHIRI Ichiro
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • YAMAZAKI Masahide
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • AOSHIMA Keiji
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • MATSUDA Tamotsu
    Third Department of Internal Medicine, Kanazawa University School of Medicine

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Other Title
  • 各種疾患における血中組織因子およびtissue factor pathway inhibitor
  • カクシュ シッカン ニ オケル ケッチュウ ソシキ インシ オヨビ tissu

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Abstract

We measured plasma levels of tissue factor (TF), total tissue factor pathway inhibitor (TFPI) and free TFPI antigen in patients with diabetes mellitus (DM), hyperlipidemia and disseminated intravascular coagulation (DIC). The mean TF, total TFPI and free TFPI antigen concentrations were significantly higher in patients with DM than in controls and the plasma TF concentration was significantly higher in patients with retinopathy or nephropathy than in DM with no complications. The mean TF, total TFPI and free TFPI antigen concentrations were significantly higher in patients with hyperlipidemia than in controls. There was a significant positive correlation between levels of total TFPI and total cholesterol. In patients with hyperlipidemia, the level of total TFPI was significantly decreased compared to base line level by cholesterol lowering drug, however, free TFPI concentration did not change by cholesterol lowering drug. The TF and total TFPI concentrations were significantly higher in patients with DIC than in controls.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 37 (9), 794-798, 1996

    The Japanese Society of Hematology

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