Clinical significance of endoscopic methylene blue staining for intestinal metaplasia in barrett's epithelium.

• KAGAWA Toshiyuki

  The Third Department of Internal Medicine, Kagawa Medical University

• MATSUDA Kazuya

  Matsuda Clinic

• UCHIDA Yoshihito

  Department of integrated medicine, Kagawa Medical University

• ITOH Minako

  The Third Department of Internal Medicine, Kagawa Medical University

• KAWABATA Hidehiro

  Department of Internal Medicine, Katoh Hospital

• KAMANO Syuhei

  Department of Internal Medicine, Katoh Hospital

• KATOH Tetsuo

  Department of Internal Medicine, Katoh Hospital

• NISHIOKA Mikio

  The Third Department of Internal Medicine, Kagawa Medical University

• KURIYAMA Shigeki

Bibliographic Information

Other Title

• Ｂａｒｒｅｔｔ上皮における腸上皮化生のメチレンブルー染色法を用いた内視鏡的検討

Abstract

BACKGROUND & AIM: Intestinal metaplasia in Barrett's epithelium has been shown to be associated with adenocarcinoma. It is, however, difficult to endoscopically detect intestinal metaplasia in Barrett's epithelium. The aim of this study was to evaluate the usefulness of methylene blue staining for detecting intestinal metaplasia in Barrett's epithelium. METHODS: We performed upper endoscopy with methylene blue-directed biopsy and obtained 83 biopsy specimens (57 stained and 26 unstained) from 24 Japanese patients with Barrett's epithelium, 1 cm or more in length. All specimens were examined histologically. RESULTS: The sensitivity and specificity of methylene blue staining for detecting intestinal metaplasia were 98.2% and 92.6%, respectively. Patients with short or limited length of Barrett's epithelium have a focal distribution of intestinal metaplasia. CONCLUSIONS: Methylene blue staining is a useful method for detecting intestinal metaplasia in Barrett's epithelium and may aid the endoscopist in selective biopsies from Barrett's epithelium.

Journal

• GASTROENTEROLOGICAL ENDOSCOPY

  GASTROENTEROLOGICAL ENDOSCOPY 43 (10), 1997-2004, 2001

  Japan Gastroenterological Endoscopy Society

Keywords

• Barrett食道
• 腸上皮化生
• メチレンブルー染色

Details

• CRID: 1390282679192670976
• NII Article ID: 130004254457
• NII Article ID: 10008043470
• NII Book ID: AN00192102
• DOI: 10.11280/gee1973b.43.1997
• ISSN: 18845738
• ISSN: 03871207
• Web Site: https://search.jamas.or.jp/link/ui/2002094258
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed