免疫組織学的検討を行った十二指腸平滑筋肉腫の1例  [in Japanese] A CASE OF LEIOMYOSARCOMA IN THE DUODENUM WITH IMMUNOHISTOCHEMICAL ANALYSIS  [in Japanese]

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Abstract

症例は69歳,男性.著明な貧血による息切れを主訴に来院.内視鏡検査で十二指腸下行脚内腔を占める表面無構造で汚い潰瘍形成を伴う腫瘍を認めた.膵頭十二指腸切除術が施行された.病理組織学的に強い核分裂像を有する異型の強い紡錘形細胞が十二指腸粘膜内へ逆行性に浸潤し潰瘍を形成していた.免疫組織学でc-kit,CD34はともに陰性を示し,α-smooth muscle actinが陽性を示したことより,十二指腸原発平滑筋肉腫と診断した.

A 69-year-old male was admitted to our hospital with a complaint of dyspnea on exertion due to severe anemia. An upper GI endoscopy revealed that a large tumor occupied in the second portion of the duodenum. The tumor lacked regular surface mucosal structure, showing irregular ulcerations. Pancreaticoduodenectomy was performed. Histopathologically, atypical spindle-shaped cells with severe mitotic figures were invaded from the muscle layer to the duodenal mucosa with ulcer formation. Immunohistochemical examination showed that the tumor cells were positive for a-smooth muscle actin, but negative for c-kit and CD34. We report a case of leiomyosarcoma in the duodenum with notable endoscopic feature, referring to the importance of immunohistochemical analyses on gastrointestinal mesenchymal tumor (GIRT).

Journal

  • GASTROENTEROLOGICAL ENDOSCOPY

    GASTROENTEROLOGICAL ENDOSCOPY 43(12), 2231-2236, 2001-12-20

    Japan Gastroenterological Endoscopy Society

References:  15

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008043858
  • NII NACSIS-CAT ID (NCID)
    AN00192102
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03871207
  • Data Source
    CJP  CJPref  J-STAGE 
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