Protection against Malignant Progression of Spontaneously Developing Liver Tumors in Transgenic Mice Expressing O^6-Methylguanine-DNA Methyltransferase
-
- QIN Xiusheng
- Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo
-
- ZHANG Shaomin
- Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo
-
- MATSUKUMA Shoichi
- Kanagawa Cancer Center Research Institute
-
- ZARKOVIC Mirjana
- Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo
-
- SHIMIZU Seiichiro
- Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo
-
- ISHIKAWA Takatoshi
- Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo
-
- NAKATSURU Yoko
- Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo
Search this Article
Author(s)
-
- QIN Xiusheng
- Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo
-
- ZHANG Shaomin
- Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo
-
- MATSUKUMA Shoichi
- Kanagawa Cancer Center Research Institute
-
- ZARKOVIC Mirjana
- Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo
-
- SHIMIZU Seiichiro
- Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo
-
- ISHIKAWA Takatoshi
- Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo
-
- NAKATSURU Yoko
- Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo
Journal
-
- Japanese journal of cancer research : gann
-
Japanese journal of cancer research : gann 91(11), 1085-1089, 2000-11-30
References: 28
-
1
- O^6-methylguanine-DNA methyltransferase activity in the human lung persists with advancing age
-
NAKATSURU Y.
Gerontology 40(Suppl.2), 3-9, 1994
Cited by (1)
-
2
- Mechanism of mutagenesis by O^6-methylguanine
-
EADIE J. S.
Nature 308, 201-203, 1984
Cited by (2)
-
3
- Site-specific mutagenesis by O^6-alkylguanines located in the chromosomes of mammalian cells: influence of the mammalian O^6-alkylguanine-DNA alkyltransferase
-
ELLISON K. S.
Proc. Natl. Acad. Sci. USA 86, 8620-8624, 1989
Cited by (2)
-
4
- Induction of mammary carcinomas in rats by nitrosomethylurea involves malignant activation of H-ras-1 locus by single point mutations
-
SAKUMAR S.
Nature 306, 658-661, 1983
DOI Cited by (12)
-
5
- Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines
-
BELINSKY S. A.
Cancer Res 49, 5305-5311, 1989
Cited by (8)
-
6
- Mutational activation of the cellular Harvey ras oncogene in rat esophageal papillomas induced by methylbenzylnitrosamine
-
WANG Y.
Cancer Res. 50, 1591-1595, 1990
Cited by (3)
-
7
- Mammalian O^6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.
-
PEGG A. E.
Cancer Res. 50, 6119-6129, 1990
Cited by (12)
-
8
- DNA repair enzymes.
-
RINDAHL T.
Ann. Rev. Biochem. 51, 61-87, 1982
Cited by (2)
-
9
- Comparison of O^6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues
-
GERSON S. L.
Carcinogenesis 7, 745-749, 1986
DOI Cited by (6)
-
10
- Age and strain dependence of O^6-methylguanine DNA methyltransferase activity in mice
-
NAKATSURU Y.
Mutat Res 219, 51-56, 1989
DOI Cited by (4)
-
11
- Persistence of O^6-ethylguanine in rat-brain DNA : correlation with nervous system-specific carcinogenesis by ethylnitrosourea
-
GOTH R.
Proc Natl Acad Sci USA 71, 639-643, 1974
DOI Cited by (4)
-
12
- Dose-response relationship between O^6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
-
BELINSKY S. A.
Cancer Res 50, 3772-3780, 1990
Cited by (5)
-
13
- Repair of O^6-ethylguanine in DNA protects rat 208F cells from tumorigenic conversion by N-ethyl-N-nitrosourea
-
THOMALE J.
Proc. Natl. Acad. Sci. USA 87, 9883-9887, 1990
Cited by (1)
-
14
- Reduced O^6-methyl-guanine repair in fibroblast cultures from patients with lung cancer
-
RUDIGER H. W.
Cancer Res 49, 5623-5626, 1989
Cited by (2)
-
15
- O^6-Methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis
-
NAKATSURU Y.
Proc Natl Acad Sci USA 90, 6468-6472, 1993
DOI Cited by (6)
-
16
- The prevention of thymic lymphoma in transgenic mice by human O^6-alkylguanine-DNA alkyltransferase
-
DUMENCO L. L.
Science 259, 219-222, 1993
Cited by (6)
-
17
- Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon
-
ZAIDI N. H.
Carcinogenesis 16, 451-456, 1995
Cited by (5)
-
18
- Reduced lung tumorigenesis in human methylguanine DNA-methyltransferase transoenic mice achieved by expression of transgene within the target cell
-
LIU L.
Carcinogenesis 20, 279-284, 1999
Cited by (2)
-
19
- Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, threshold and defense mechanisms
-
KAINA B.
Mutat. Res. 405, 179-191, 1998
Cited by (1)
-
20
- Genetic control of hepatocarcinogenesis in C57BL/6J and C3H/HeJ inbred mice
-
DRINKWATER N. R.
Carcinogenesis 7, 1701-1707, 1986
DOI Cited by (5)
-
21
- Analysis of the Ha-ras oncogene in C3H/He mouse liver tumors derived spontaneously or induced with diethylnitrosamine or phenobarbitone
-
RUMBY P. C.
Carcinogenesis 12, 2331-2336, 1991
Cited by (2)
-
22
- Enhanced O^6-methylguanine-DNA methyltransferase activity in transgenic mice containing an integrated E. coli ada repair gene
-
MATSUKUMA S.
Mutat Res 218, 197-206, 1989
Cited by (2)
-
23
- Mutational analysis of the H-ras oncogene in spontaneous C57BL/6×C3H/He mouse liver tumors induced with genotoxic and nongenotoxic hepatocarcinogens
-
FOX T. R.
Cancer Res 50, 4014-4019, 1990
Cited by (6)
-
24
- Ras proto-oncogene activation in liver and lung tumors from B6C3F_1 mice exposed to methylene chloride.
-
DEVEREUX T. R.
Carcinogenesis 14, 795-801, 1993
Cited by (4)
-
25
- Activated oncogenes in B6C3F1 mouse liver tumors : Implications for risk assessment
-
REYNOLD S. R.
Science 237, 1309-1361, 1987
Cited by (7)
-
26
- The Hcr (hepatocarcinogen resistance) loci of DBA/2J mice partially suppress phenotypic expression of the Hcs (hepatocarcinogen sensitivity) loci of C3H/HeJ mice
-
LEE G. H.
Carcinogenesis 16, 1993-1996, 1995
Cited by (2)
-
27
- Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT
-
QIN X.
Oncogene 29, 4394-4400, 1999
Cited by (1)
-
28
- Targeted disruption of the DNA repair methyltrasferase gene renders mice hypersensitive to alkylating agent
-
TSUZUKI T.
Carcinogenesis 17, 1215-1220, 1996
Cited by (3)