Suppression of Human Pancreatic Cancer Growth in BALB/c Nude Mice by Manumycin, a Farnesyl:protein Transferase Inhibitor

• Toshio Ito

• Sumio Kawata

• Shinji Tamura

• Takumi Igura

• Toshihiko Nagase

• Jun‐ichiro Miyagawa

• Eiji Yamazaki

• Hiroshi Ishiguro

• Yuji Matsuzawa

抄録

Activating mutations of Ki‐ ras have been detected in most human pancreatic adenocarcinomas. Since Ras protein requires farnesylation to function, we investigated the effects of manumycin, a potent farnesyl:protein transferase inhibitor, on the growth in nude mice of a human pancreatic cancer cell line, MIA PaCa‐2, with a point mutation in the Ki‐ ras gene. Tumor‐bearing mice received intraperitoneal injection of 1 or 5 mg/kg manumycin daily for 5 days, or 2 mg/kg manumycin daily for 2 weeks. Growth of inoculated tumors was significantly inhibited by the treatment. The treatment significantly (P<0.05) lowered the numbers of bromodeoxyuridine‐incorporating tumor cells. Manumycin did not have apparent hepatotoxicity in vivo . Farnesyl:protein transferase inhibitors could offer a new approach for cancer chemotherapy.

収録刊行物

• Japanese Journal of Cancer Research

  Japanese Journal of Cancer Research 87 (2), 113-116, 1996-02

  Wiley

キーワード

• Cancer Research
• Oncology

詳細情報

• CRID: 1364233269372925184
• NII論文ID: 10008071697
• NII書誌ID: AA00690844
• DOI: 10.1111/j.1349-7006.1996.tb03146.x
• ISSN: 09105050
• ISSN: http://id.crossref.org/issn/09105050
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1349-7006.1996.tb03146.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1349-7006.1996.tb03146.x
• Web Site: https://search.jamas.or.jp/link/ui/1996155580
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