Intracellular Hyperthermia for Cancer Using Magnetite Cationic Liposomes: Ex vivo Study

• Mitsugu Yanase

• Masashige Shinkai

• Hiroyuki Honda

• Toshihiko Wakabayashi

• Jun Yoshida

• Takeshi Kobayashi

抄録

Heating properties of magnetite cationic liposomes (MCL) were investigated in ex vivo experiments using implanted cell pellets. The cell pellets, which consisted of rat glioma T9 cells into which MCL had been incorporated in a petri dish, were implanted subcntaneously in the left femoral region of female F344 rats. The rats were placed in a magnetic field generating coil and irradiated with an alternating magnetic field (384 Oe, 118 kHz) for 60 min. The cell pellets were heated to over 43°C by MCL in the magnetic field, hut other body parts of the rats were not heated. After 3 cycles of magnetic heating, all glioma cells were killed and no tumor take was observed.

収録刊行物

• Japanese Journal of Cancer Research

  Japanese Journal of Cancer Research 88 (7), 630-632, 1997-07

  Wiley

キーワード

• Cancer Research
• Oncology

詳細情報

• CRID: 1362544420739626112
• NII論文ID: 10008079768
• NII書誌ID: AA00690844
• DOI: 10.1111/j.1349-7006.1997.tb00429.x
• ISSN: 09105050
• ISSN: http://id.crossref.org/issn/09105050
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1349-7006.1997.tb00429.x
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1349-7006.1997.tb00429.x
• Web Site: https://search.jamas.or.jp/link/ui/1998031395
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