咽喉頭異常感症難治例の多剤併用薬物治療  [in Japanese] Clinical Evaluation of Combined Use of Azelastine Hydrochloride, Roxithromycin, Tofisopam and Saiboku-to for Throat Discomfort Unsuccessfully Treated by Previos Physicians  [in Japanese]

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Author(s)

Abstract

Between 1997 and 1999 the author treated 100 patients (50 male and 50 female, aged from 15 to 76 years with a mean age of 56.2; 44 allergic and 56 non-allergic) with intractable throat discomfort that had not previously responded to medical treatment. Azelastine hydrochloride (anti-allergic agent, Azeptine° 2mg/day), roxithromycin (synthesized macrolide antibiotic, Rurid°300mg/day), tofisopam (a derivative of 2, 3-benzodiazepine effective for autonomic nerve dysfunction, Grandaxin°150mg/day) and Saiboku-to (Chinese herbal medicine for abnormal sensation and inflammation in the upper airway, Tsumura Saiboku-to Extract Granules° 7.5g/day) were administered in combination to the 44 allergic patients and the latter 3 medicines only to the 56 non-allergic patients for a total of 2 weeks.<br>The therapeutic effect of the combined medication was evaluated at the end of the first and second weeks of administration and one week after the termination of treatment. The medication was considered to be markedly effective when discomfort improved by 80% or more, moderately effective with a 50-79% improvement, slightly effective with a 20-49% improvement, and not effective if the improvement was less than 20%.<br>The medication was markedly effective in 31% and moderately effective in 35% of patients at the end of the first week; the corresponding figures were 37% and 34% at the end of the second week, and 38% and 30% one week after the termination of medication, respectively.<br>These findings indicate that the combined medication was effective in the therapy of patients with intractable throat discomfort.

Journal

  • Practica Oto-Rhino-Laryngologica

    Practica Oto-Rhino-Laryngologica 94(8), 751-759, 2001-08-01

    The Society of Practical Otolaryngology

References:  31

Codes

  • NII Article ID (NAID)
    10008097398
  • NII NACSIS-CAT ID (NCID)
    AN00107089
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    00326313
  • Data Source
    CJP  J-STAGE 
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