Bell麻痺と単純ヘルペスウイルス  [in Japanese] Bell's Palsy and Herpes Simplex Virus  [in Japanese]

Access this Article

Author(s)

Abstract

Bell's palsy is the most common cause of facial paralysis; it has an incidence of 20 to 30 per 100, 000 people. Many events such as viral infection, is chemia and autoimmune reaction have been proposed as causes of Bell's palsy. However, to date there have been no reports of conclusive evidence of the etiological agent responsible for Bell's palsysince Sir Charles Bell described the disease in 1830. Because the etiological agent remains unknown, treatment of this condition is empiric, varying from observation alone to the use of steroids and surgical decompression.<br>Recent advancements in the molecular methods of <i>in situ</i> hybridization and polymerase chain reaction have revealed the existence of HSV-1 genomes in the involved facial nerve as well as the geniculate ganglion. In addition, animal experiments have shown that HSV-1 may induce facial paralysis and the beneficial effect of the antiviral agent of acyclovir for facial function has also been demonstrated. These findings provide the evidence that latently infected HSV-1 causes Bell's palsy when it reactivates and it is controversial whether we should continue using the term “Bell's palsy” to mean “idiopathic facial paralysis” or whether we should now recognize Bell's palsy as “herpetic facial paralysis”. However, currently, we have no reliable, widely available clinical test for the early identification of HSV-1 infection in Bell's patients. Methodological break-through will resolve this problem and data accumulation will datermine the percentage of patients with Bell's palsy in whom HSV-1 is the etiological agent.

Journal

  • Practica Oto-Rhino-Laryngologica

    Practica Oto-Rhino-Laryngologica 94(10), 857-868, 2001-10-01

    The Society of Practical Otolaryngology

References:  70

Codes

  • NII Article ID (NAID)
    10008097694
  • NII NACSIS-CAT ID (NCID)
    AN00107089
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    00326313
  • NDL Article ID
    5925798
  • NDL Source Classification
    ZS43(科学技術--医学--耳鼻咽喉科学)
  • NDL Call No.
    Z19-421
  • Data Source
    CJP  NDL  J-STAGE 
Page Top