喉頭癌放射線治療での麦門冬湯の咽頭痛予防 Bakumondo-to Appears to Alleviate Radiation-Induced Mucositis in Early Laryngeal Carcinoma

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PURPOSE: Tsumura Co.'s Bakumondo-to (TJ-29) is a Chinese herb medicine prescribed widely in Japan for bronchitis and laryngitis. It is well known that TJ-29 not only has a variety of effects including anti-inflammatory and antitussive properties, but also is capable of increasing salivary secretions. The purpose of this study is to examine whether TJ-29 can reduce mucosal toxicity caused by radiotherapy in patients with early laryngeal carcinoma.<br>METHODS AND MATERIALS: Between 1993 and 1999, 20 patients with primary early laryngeal carcinoma were treated by radiotherapy at Nagato General Hospital. All patients were treated with 2 Gy per fraction daily, 5 days a week. Eight patients formed the control group (no TJ-29) and 12 patients received TJ-29 throughout the radiation therapy. The severity of daily subjective symptoms such as hoarseness, xerostomia or pharyngoxerosis, cough, and sore throat were graded O to 3 according to descriptions on the clinical charts.<br>RESULTS: No statistically significant between-group differences were seen in subjective hoarseness, xerostomia or pharyngoxerosis, and cough. However the mean final grade of subjective sore throat was less severe in the TJ-29 group (p=0.023).<br>CONCLUSION: Despite the limited number of patients, this study suggests that TJ-29 was able to reduce the severity of mucositis induced by radiotherapy. Further intensive research is needed.

収録刊行物

  • 耳鼻咽喉科臨床

    耳鼻咽喉科臨床 95(2), 203-209, 2002-02-01

    耳鼻咽喉科臨床学会

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各種コード

  • NII論文ID(NAID)
    10008099093
  • NII書誌ID(NCID)
    AN00107089
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00326313
  • データ提供元
    CJP書誌  J-STAGE 
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