A Case of Small Cell Lung Cancer that Developed during Therapy for Myasthenia Gravis.
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- Miyoshi Reiko
- First Department of Internal Medicine, Kagawa Medical School
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- Yamaji Yasufumi
- First Department of Internal Medicine, Kagawa Medical School
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- Shima Satsuki
- First Department of Internal Medicine, Kagawa Medical School
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- Fujita Jiro
- First Department of Internal Medicine, Kagawa Medical School
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- Okada Hiroki
- 香川医科大学総合診療部
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- Takahara Jiro
- First Department of Internal Medicine, Kagawa Medical School
Bibliographic Information
- Other Title
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- 重症筋無力症の治療・経過観察中に発症した肺小細胞癌の1例
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Abstract
A 56-year-old man had been complaining of progressive proximal muscle weakness and bilateral ptosis before his first admission to our hospital. He received an injection of edrophonium chloride, which resulted in remarkable improvement of muscle strength. Electromyographic studies revealed a compound muscle action potential that decreased after repetitive stimulation at a high rate (15Hz). He was regarded as having myasthenia gravis (MG) rather than Eaton-Lambert syndrome because of these findings. Eighteen months after successful treatment of MG with oral anticholinesterase medication, he complained of an abdominal mass. The mass was found to be a tumor that had metastasized from a primary small cell carcinoma of the lung. Cases of MG with small cell carcinoma of the lung seem to be very rare, and the details of the relationship between them remain unknown. In this patient, MG may have developed by paraneoplastic mechanisms. This hypothesis is intersting, since it has been demonstrated recently by molecular biological techniques that small cell carcinomas of the lung express nicotinic acetylcholine receptors.
Journal
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- The Japanese journal of thoracic diseases
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The Japanese journal of thoracic diseases 33 (4), 456-462, 1995
The Japanese Respiratory Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001205017187456
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- NII Article ID
- 10008107074
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- NII Book ID
- AN00187758
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- ISSN
- 1883471X
- 03011542
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- PubMed
- 7791277
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- Text Lang
- ja
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- Data Source
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- JaLC
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed