非定型抗酸菌症患者末梢血単球のＴＮＦα，ＩＬ‐６産生能の検討　臨床活動性との関連について

DOI PubMed 参考文献20件

書誌事項

タイトル別名
  • Production of Tumor Necrosis Factor Alpha and Interleukin-6 by Peripheral Monocytes from Patients with Atypical Mycobacteriosis. Relationship to Clinical Activity.
  • Relationship to Clinical Activity
  • 臨床活動性との関連について

この論文をさがす

抄録

The production of tumor necrosis factor alpha (TNF—) and of interleukin-6 (IL-6) by peripheral blood monocytes (PBMs) from patients infected with Mycobacerium avium intracellular complex (MAC) were assessed.<br>Spontaneous release of both TNF— and IL-6 were greater during the active stage than during the inactive stage and in healthy controls. When the cells were stimulated with MAC-derived purified protein derivative B (PPD-B), TNF— production by PBMs in the active stage increased and IL-6 production by cells in both the active and inactive stages decreased.<br>Moreover, the in vitro increase in TNF— production after stimulation in the active stage seemed to be related to the persistent MAC infection, which resulted in an exhaustion of nutrition.<br>These results suggest that the ability of PBMs to produce TNF— and IL-6 in vitro is closely related to the clinical stage of MAC infection.

収録刊行物

参考文献 (20)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ