Interleukin-2 Activity in Monocrotaline-treated Rat Lungs.

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  • Suzuki Atsuo
    Department of Chest Medicine, Institute of Pulmonary Cancer Research, School of Medicine, Chiba University
  • Kakusaka Ikuei
    Department of Chest Medicine, Institute of Pulmonary Cancer Research, School of Medicine, Chiba University
  • Kaneko Noboru
    Department of Chest Medicine, Institute of Pulmonary Cancer Research, School of Medicine, Chiba University
  • Kiyatake Kunio
    Department of Chest Medicine, Institute of Pulmonary Cancer Research, School of Medicine, Chiba University
  • Nakano Kunio
    Department of Chest Medicine, Institute of Pulmonary Cancer Research, School of Medicine, Chiba University
  • Kuriyama Takayuki
    Department of Chest Medicine, Institute of Pulmonary Cancer Research, School of Medicine, Chiba University

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  • モノクロタリン投与後ラット肺におけるインターロイキン‐２活性能の経時的変化について

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Abstract

To study the relationship between cytokines and the development of monocrotaline-induced pulmonary hypertension, monocrotaline was given and interleukin-2 was measured. The amount of interleukin-2 produced by pulmonary cells obtained by bronchoalveolar lavage was high only on the 14th day after monocrotaline injection (p<0.01). This suggests that many kinds of cells in the monocrotaline-treated rat lung were activated by cytokines, and that these interactions play an important role in the development of monocrotaline-induced pulmonary hypertension in rats.

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