感作ウサギの過換気誘発気道収縮（ＨＩＢ）に対するβ２刺激薬，ＤＳＣＧ，抗コリン薬の効果

DOI PubMed 被引用文献1件 参考文献15件

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  • Effects of a .BETA.2-agonist, Sodium Cromoglycate, and an Anticholinergic Agent on Hyperventilation-induced Bronchoconstriction in Sensitized Rabbits.

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Hyperventilation can induce bronchoconstriction in ovalbumin-sensitized rabbits. To investigate the roles of the β-receptor parasympathetic nervous system and of chemical mediators in hyperventilation-induced bronchoconstriction (HIB), the effects of a β2-agonist, of sodium cromoglycate, and of an anticholinergic agent on HIB were studied. Rabbits were divided to four groups and treated as follows. Group 1: Control (n=7, 0.9% saline); Group 2: Procaterol (n=4, 50μg/l); Group 3: Sodium cromoglycate (n=4, 10mg/ml); and Group 4: Ipratropium bromide (n=6, 1mg/ml). Each drug was inhaled for 1min via an ultrasonic nebulizer. Then, for the eucapnic hyperventilation challenge, sensitized rabbits were mechanically hyperventilated for 15min (120 breaths/min, tidal volume=7ml/kg) with dry air containing 5% CO2 at room temperature. Total lung resistance and dynamic compliance were measured before, and 0. 5, 15, and 30min after hyperventilation. The mean percent change in resistance measured 5min after the hyperventilation was +49% in group 1, -6% in group 2, +23% in group 3, and +10 in group 4. The changes in groups 2 and 4 were significantly less than in group 1 (p<0.05).<br>In conclusion, HIB is mainly caused by bronchial smooth muscle constriction, and chemical mediators and the parasympathetic nervous system may play important roles in the development of HIB in sensitized rabbits.

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