Sarcoidosis with Hypercalcemia and Increased 1.ALPHA., 25-dihydroxyvitamin D in Lung Tissue.

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  • 高カルシウム血症を合併したサルコイドーシスの１例　肺組織中の１α，２５‐ｄｉｈｙｄｒｏｘｙｖｉｔａｍｉｎ　Ｄ含量増加について

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Abstract

A 60-year-old woman was admitted to our hospital complaining of nausea, thirst, and dyspnea on exertion. She had skin eruptions on her back and right knee. Her serum calcium level was 12.6mg/dl. The chest roentgenogram showed diffuse nodular shadows in both lung fields. The level of angiotensin-converting enzyme in serum was markedly high, and epithelioid cell granulomas were found in the specimens obtained by skin biopsy and by transbronchial lung biopsy. Sarcoidosis was diagnosed. After administration of prednisolone, the serum calcium level decreased to within the normal range and the shadows on the chest roentcenogram resolved.<br>Hypercalcemia complicated with sarcoidosis is caused by overproduction of 1α, 25-dihydroxyvitamin D in granulomas. The content of 1α, 25-dihydroxyvitamin D in the transbronchial lung biopsy specimen from this patient was higher than that from a sarcoidosis patient whose serum calcium level was normal.<br>A few case reports of sarcoidosis with hypercalcemia have been published in Japan. The association with HLA type and the possibility of overintake of dietary vitamin D are discussed in reference to hypercalcemia in this patient.

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