Effects of Inhaled Oxitropium Bromide, an Anticholinergic Drug, on Pulmonary Hemodynamics in Patients with Chronic Obstructive Pulmonary Diseases.

DOI PubMed 1 Citations 15 References
  • Saito Shunichi
    The First Department of Medicine, Hokkaido University School of Medicine
  • Miyamoto Kenji
    The First Department of Medicine, Hokkaido University School of Medicine
  • Aida Akira
    The First Department of Medicine, Hokkaido University School of Medicine
  • Saito Hiroshi
    The First Department of Medicine, Hokkaido University School of Medicine
  • Sato Fumihiko
    The First Department of Medicine, Hokkaido University School of Medicine
  • Tsujino Ichizo
    The First Department of Medicine, Hokkaido University School of Medicine
  • Nakano Tsuyoshi
    The First Department of Medicine, Hokkaido University School of Medicine
  • Nishimura Masaharu
    The First Department of Medicine, Hokkaido University School of Medicine
  • Kawakami Yoshikazu
    The First Department of Medicine, Hokkaido University School of Medicine

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  • 吸入用抗コリン薬Ｏｘｉｔｒｏｐｉｕｍ　ｂｒｏｍｉｄｅが慢性閉塞性肺疾患患者の肺循環動態に及ぼす影響

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Abstract

We studied the effects of the inhaled anticholinergic agent oxitropium bromide (Ox) on pulmonary hemodynamics in eleven patients with chronic obstructive pulmonary disease. All the patients underwent right heart catheterization and seven of them underwent an incremental ergometer exercise test while in the supine position. Pulmonary hemodynamics and arterial blood gases were measured at rest and during maximal exercise, before and 30 minutes after inhalation of 2 puffs (200μg) of Ox. Inhalation of Ox did not significantly change pulmonary hemodynamics at rest. The mean pulmonary arterial pressure and the mean pulmonary capillary wedge pressure during exercise decreased significantly (from 40.3±4.6 to 37.7±3.9mmHg, and from 20.4±3.5 to 17.1±2.7mmHg, respectively, mean±SE). However, neither cardiac output nor pulmonary vascular resistance changed with inhalation of the drug, at rest or during exercise. We therefore conclude that this commonly used dose of Ox does not directly affect the pulmonary vascular system. The small but significant decreases in pulmonary arterial pressure and pulmonary capillary wedge pressure with Ox may have been indirect effects, caused by bronchodilation.

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