書誌事項
- タイトル別名
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- Effect of Time in Culture on Modulation of Na+-K+-ATPase Activity in Rat Alveolar Type II Cells.
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抄録
To determine the effect of time in culture on epithelial cell function, we evaluated the modulation of Na+-K--ATPase activity in rat alveolar type II cells in culture. Ouabain sensitivity testing revealed that the alpha-1 predominance in the enzyme's isoforms was maintained over the 120 hours in culture. Basal Na+-K+-ATPase activity in the whole cell homogenate did not differ significantly between cells cultured for 48 hours and those cultured for 120 hours. Terbutaline (10mM) did not activate Na+-K+-ATPase in the cells cultured for 48 hours, but, it significantly increased the activity of this enzyme in the cells cultured for 120 hours cells cultured for 48 hours, produced intracellular cyclic AMP after exposure to 10mM of terbutaline. These results indicate that the coupling between Na+-K+-ATPase and the beta-adrenergic pathway in alveolar type II cells can be influenced by the time in cell culture.
収録刊行物
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- 日本胸部疾患学会雑誌
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日本胸部疾患学会雑誌 34 (5), 506-510, 1996
社団法人 日本呼吸器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205019198592
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- NII論文ID
- 130003679271
- 10008109702
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- NII書誌ID
- AN00187758
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- ISSN
- 1883471X
- 03011542
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- PubMed
- 8753107
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可