Effects of Intravenous 2-chloroadenosine on Endotoxin-Induced Acute Lung Injury.
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- Ishizaka Akitoshi
- Department of Medicine, School of Medicine, Keio University
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- Sakamaki Fumio
- Department of Medicine, School of Medicine, Keio University
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- Sayama Kouichi
- Department of Medicine, School of Medicine, Keio University
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- Urano Tetsuya
- Department of Medicine, School of Medicine, Keio University
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- Nakamura Hidetoshi
- Department of Medicine, School of Medicine, Keio University
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- Terashima Takeshi
- Department of Medicine, School of Medicine, Keio University
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- Waki Yasuhiro
- Department of Medicine, School of Medicine, Keio University
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- Soejima Kenzo
- Department of Medicine, School of Medicine, Keio University
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- Tasaka Sadatomo
- Department of Medicine, School of Medicine, Keio University
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- Kanazawa Minoru
- Department of Medicine, School of Medicine, Keio University
Bibliographic Information
- Other Title
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- エンドトキシン急性肺損傷における2クロロアデノシン静脈内投与の作用
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Abstract
To assess the effects of 2-chloroadenosine (2CA) on acute lung injury caused by endotoxin (lipopolysaccharide), guinea pigs were given 2CA intravenously. Three groups were used: saline control, endotoxin control and 2CA+ endotoxin. In the endotoxin and 2CA+ endotoxin groups, neutrophils accumulated in bronchoalveolar lavage fluid and in lung tissue. Howevre, neutrophil accumulation did not differ significantly between the endotoxin and the 2CA+ endotoxin groups. The number of macrophages in bronchoalveolar lavage fluid was signficantly higher in the endotoxin group than in the saline control group, but the difference between the saline control and the 2CA+ endotoxin groups was not significant. The lung wet-dry weight ratio and 125I-albumin lung tissue-plasma ratio, which were used to measure acute lung injury, were significantly higher in the endotoxin group than in the 2CA+ endotoxin and the saline control groups. However, these ratios did not differ between the 2CA+ endotoxin and the saline control groups. These results suggest that 2CA attenuated endotoxin induced acute lung injury in guinea pigs.
Journal
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- The Japanese journal of thoracic diseases
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The Japanese journal of thoracic diseases 34 (6), 665-670, 1996
The Japanese Respiratory Society
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Details
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- CRID
- 1390282679993594624
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- NII Article ID
- 130003679293
- 10008110130
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- NII Book ID
- AN00187758
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- ISSN
- 1883471X
- 03011542
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- PubMed
- 8741532
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- Text Lang
- ja
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- Data Source
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- JaLC
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed