書誌事項
- タイトル別名
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- Interaction between Nutrition and Production of IL-1.BETA., TNF.ALPHA., and IL-6 by Peripheral Blood Monocytes in Patients with Lung Cancer.
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抄録
Altered nutrient intake and metabolism are responsible for the progressive loss of body weight observed in most patients with advanced cancer, but the precise mechanism is still controversial. Under stressful conditions, some inflammatory cytokines such as IL-1β, TNFα, and IL-6 have a hypermetabolic effect and cause proteolysis and lipolysis in muscle and in fat tissues. To elucidate the mechanism of malnutrition in patients with lung cancer and normal food intake, we focused on the relationship between abnormal metabolism and these inflammatory cytokines.<br>Patients with lung cancer were confirmed to be malnourished, and this malnutrition was found to be caused by hypermetabolism as estimated with visceral proteins, plasma levels of amino acids, and anthropometric indices. The production of IL-1β, TNFα, and IL-6 by blood monocytes was significantly higher in these patients than in healthy controls, and it correlated significantly and inversely with indices of nutrition.<br>The present results suggest that nutritional status and these cytokines are closely related in patients with lung cancer. IL-1β, TNFα, and IL-6 may serve as anti-cancer bioactive molecules, but “overfunctioning” of these cytokines may induce a hypermetabolic status that causes malnutrition, i. e. cancer cachexia.
収録刊行物
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- 日本胸部疾患学会雑誌
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日本胸部疾患学会雑誌 34 (7), 778-784, 1996
社団法人 日本呼吸器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205016283776
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- NII論文ID
- 130003679316
- 10008110434
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- NII書誌ID
- AN00187758
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- ISSN
- 1883471X
- 03011542
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- PubMed
- 8810759
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可