亜急性知覚神経障害で発症したａｎｔｉ‐Ｈｕ　ａｎｔｉｂｏｄｙ陽性小細胞肺癌の１例

DOI PubMed 被引用文献2件 参考文献19件

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  • Small-cell Lung Cancer and Subacute Sensory Neuropathy in a Patient Positive for the Anti-Hu Antigen.

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We encountered a case of small-cell lung cancer in a patient with subacute sensory neuropathy that began 5 months before the cancer was diagnosed. A 60-year-old man complained of abnormalities in the functioning of his peripheral sensory systems (senses of pain, touch, position, and vibration). A chest X-ray film obtained on admission showed an anterior mediastinal tumor. The anti-Hu antibody was found in his serum. The diagnosis was small-cell lung cancer. Combination chemotherapy (cisplatin and irinotecan, CPT-11) was begun and the response was a complete remission. The symptoms of neuropathy continued. The anti-Hu antibody was useful in the diagnosis in this case of small-cell lung cancer combined with subacute sensory neuropathy.

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