肺結核家族感染,職場感染分離結核菌のRestriction Fragment Length Polymorphism分析  [in Japanese] Outbreaks of Pulmonary Tuberculosis in a Family and in a Hospital Analysis of Restriction-fragment-length Polymorphisms  [in Japanese]

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Abstract

肺結核の集団感染の証明には従来より分離結核菌のファージ型別, 菌の薬剤感受性パターンが用いられてきたが日本でみられる型は2種のみであること, 分離菌の多くは抗結核剤に感受性があることよりこれらの方法は限界がある. 今回感染経路を明らかにする目的で肺結核家族発生の疑われる3例, 及び院内感染が疑われる2例の分離結核菌を用いRFLP分析 (restriction fragment length polymorphism analysis) を行なった. 各々のグループでRFLPパターンは同一であることが証明され家族感染, 院内感染の可能性がきわめて高いと考えられた.

Restriction-fragment-length polymorphism, analysis was used to study two outbreaks of pulmonary tuberculosis, one in a family and one in a hospital. The DNA probe was derived from the insertion sequence IS 6110. Two groups of isolates were analyzed, both of which were suspected to be common sources of each infection. Both groups showed identical fingerprints within each group. These results suggest that analysis of restriction-fragment-length polymorphism is useful in epidemiological studies of pulmonary tuberculosis.

Journal

  • The Japanese journal of thoracic diseases

    The Japanese journal of thoracic diseases 34(10), 1098-1103, 1996-10-25

    The Japanese Respiratory Society

References:  12

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008111181
  • NII NACSIS-CAT ID (NCID)
    AN00187758
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03011542
  • Data Source
    CJP  CJPref  J-STAGE 
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