喀疾より Neisseria meningitidis が分離された両側性肺炎の1例  [in Japanese] Bilateral Meningococcal Pneumonia in a Young Japanese Woman  [in Japanese]

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Abstract

22歳, 女性. 発熱, 食欲低下, 咳嗽, 喀痰, 右胸痛を主訴として来院. 胸部X線写真上, 両肺野に浸潤影を認め, 喀痰より<i>Neisseria meningitidis</i> が検出されたため, 本菌による両側性肺炎と診断した. <i>N. meningitidis</i> は本邦には常在せず, その感染症は輸入感染症とする考えもあるが, 本例は海外渡航歴がなく感染経路を特定できなかった. 本菌による呼吸器感染は稀であり, その場合でも多くは気管支炎に止まり, 肺炎にまで至る症例は極めて少ない. 本菌の易感染性要因である後期補体成分欠損は認められず, 免疫能にも異常はなかった. しかし, 本例は著明なるいそうがみられる上, 検査上も低栄養状態にあったことが分かっており, それが発症要因の一つになったと推測された. 治療にはニューキノロン系抗菌薬である DU6859a を経口投与し著効を示した.

A 22-year-old woman was admitted to the hospital with complaints of fever, loss of appetite, coughing, sputum production, and right-sided chest pain. The chest X-ray film and computed tomogram showed infiltrates in both lower lung fields. Meningococcal pneumonia was diagnosed when a sputum culture was found to be positive for <i>Neisseria meningitidis</i>. Infection with this organism is uncommon in Japan. The patient had never gone abroad, and the route of infection was unknown.<br><i>N. meningitidis</i> is a rare cause of respiratory infections. When this organism does cause respiratory disease, it is usually acute bronchitis rather than meningococcal pneumonia. The patient in this case was not immunodeficient. She was also not deficient in a terminal lytic component sequence (deficiency in that sequence promotes meningococcal infection). The patient was emaciated and malnourished, which was thought to have made her more susceptible to infection.<br>Orally administered DU-6859a, one of a new generation of quinolones, was very effective and had no side effects.

Journal

  • The Japanese journal of thoracic diseases

    The Japanese journal of thoracic diseases 34(10), 1121-1124, 1996-10-25

    The Japanese Respiratory Society

References:  9

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008111241
  • NII NACSIS-CAT ID (NCID)
    AN00187758
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03011542
  • Data Source
    CJP  CJPref  J-STAGE 
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