Two Patients with Idiopathic Pulmonary Fibrosis and Monoclonal Gammopathy.

DOI PubMed 19 References
  • Hanaoka Masayuki
    First Department of Internal Medicine, Shinshu University School of Medicine
  • Kubo Keishi
    First Department of Internal Medicine, Shinshu University School of Medicine
  • Yamaguchi Shinji
    First Department of Internal Medicine, Shinshu University School of Medicine
  • Hayano Toshihide
    First Department of Internal Medicine, Shinshu University School of Medicine
  • Koizumi Tomonobu
    First Department of Internal Medicine, Shinshu University School of Medicine
  • Fujimoto Keisaku
    First Department of Internal Medicine, Shinshu University School of Medicine
  • Honda Takayuki
    Central Clinical Laboratories, Shinshu University School of Medicine
  • Kobayashi Toshio
    First Department of Internal Medicine, Shinshu University School of Medicine
  • Sekiguchi Morie
    First Department of Internal Medicine, Shinshu University School of Medicine

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Other Title
  • 単クローン性免疫グロブリン血症を合併した間質性肺炎の２例

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Abstract

A 67-year-old man and a 70-year-old man were admitted to our hospital because of dyspnea and dry coughing. Chest X-ray films showed bilateral reticulonodular shadows in the middle and lower lung fields. Specimens were obtained by open-lung biopsies and the findings were compatible with those of usual interstitial pneumonia. Immunoelectrophoresis revealed monoclonal gammopathy in both patients. The levels of interleukin-6 in bronchoalveolar lavage fluid were high.<br>In these two patients, idiopathic pulmonary fibrosis was associated with multiple myeloma and monoclonal gammopathy, and the levels of interleukin-6 in bronchoalveolar lavage fluid were high. These findings may help to elucidate the pathogenesis and development of idiopathic pulmonary fibrosis.

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