家族内発生をみた夏型過敏性肺臓炎例  [in Japanese] Summer-Type Hypersensitivity Pneumonitis in a Family  [in Japanese]

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Author(s)

Abstract

5人家族でうち3人が同時期に発症した夏型過敏性肺臓炎例を経験した. 症例は, 父, 母および娘の3人で8月から9月にかけて, 咳嗽, 喀痰および呼吸困難で発症した. 娘と母は胸部X線写真上びまん性微細粒状影を呈した. 気管支肺胞洗浄液では全例に総細胞数とリンパ球分画の増多とCD4/CD8比の低下を認め, 娘から得られた経気管支肺生検では, 肉芽腫および Masson 体を伴った胞隔炎を認めた. 血清学的に <i>Trichiosporon cutaneum</i> 抗体が証明され, 夏型過敏性肺臓炎と診断した. 発症機序として, 抗原暴露などの環境因子および遺伝的素因が考えられた.

We encountered a family in which three of the five members (The parents and a daughter) had summer-type hypersensitivity pneumonitis that occurred in late summer. All three patients had a productive cough and shortness of breath. Chest roentgenograms of the mother and daughter (but not the father) showed diffuse small nodular shadows in both lung fields. Examination of bronchalveolar lavage fluid from all three patients showed very high total cell counts, high percentages of T lymphocytes, and low ratios of CD4+-to-CD8+ cells. Microscopic examination of transbronchial biopsy specimens obtained from the daughter revealed infiltration of mononuclear cells with characteristic Masson bodies in alveolar septa, and gramulomas in the interstitium. Both mother and daughter were positive for serum anti- <i>Trichosporon cutaneum</i> (serotype II) antibody, but the father, who was a current smoker, was not. Thus, both mother and daughter were given the diagnosis of summer-type hypersensitivity pneumonitis, and in the father that diagnosis was strongly suspected.

Journal

  • The Japanese journal of thoracic diseases

    The Japanese journal of thoracic diseases 34(12), 1401-1405, 1996-12-01

    The Japanese Respiratory Society

References:  9

Cited by:  4

Codes

  • NII Article ID (NAID)
    10008111975
  • NII NACSIS-CAT ID (NCID)
    AN00187758
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03011542
  • Data Source
    CJP  CJPref  J-STAGE 
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