書誌事項
- タイトル別名
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- Long-term Effects of a Selective .ALPHA.1-adrenergic Inhibitor on Right and Left Ventricular Masses in Patients with Chronic Pulmonary Disease.
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抄録
We examined the effect of one year of treatment with the selective α1-adrenergic inhibitor doxazosin on right ventricular mass (RV mass), left ventricular mass (LV mass), and arterial blood gases. The subjects were 24 outpatients (18 men and 6 women, mean age 68.3±9.4 years) with chronic pulmonary disease complicated by hypertension who were clinically stable. One year of drug therapy was associated with significant decreases both in systolic pressure (159±15.2 vs 125.8±14.1mmHg, p<0.05, n=24), and in LV mass index (101.0±13.4 vs 97.6±11.8gm-2, p<0.05, n=24). We obtained the RV mass index by multiplying the thallium score RV/LV count and the LV mass index obtained by echocardiography. One year of drug therepy was associated with a significant increase in RV mass index (42.9±31.2 vs 53.6±30.5gm-2, p<0.05, n=8). Vital capacity decreased (2.18±1.95 vs 1.95±0.57l p<0.05, n=24), but PaO2 improved (77.3±17.2 vs 82.2±2.4mmHg, p<0.05, n=24). These data indicate that doxazosin can decrease blood pressure and can depress the left ventricle with no adverse effect on oxygenation in patients with chronic pulmonary disease complicated by hypertension. The worsening of RV hypertrophy may have been caused by a mechanism different from the one that caused LV hypertrophy, and by an increase in the work load on the right ventricles secondary to lung deterioration.
収録刊行物
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- 日本胸部疾患学会雑誌
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日本胸部疾患学会雑誌 35 (1), 30-37, 1997
社団法人 日本呼吸器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205017430656
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- NII論文ID
- 130003679374
- 10008112132
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- NII書誌ID
- AN00187758
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- ISSN
- 1883471X
- 03011542
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- PubMed
- 9071153
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可