Serodiagnosis with Trehalose-6,6'-dimycolate of Pulmonary Tuberculosis.
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- Wada Masako
- Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association
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- Abe Chiyoji
- Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association
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- Kohno Hiroaki
- Kyowa Medex Fuji Research Laboratory
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- Kawamura Mizuho
- Kyowa Medex Fuji Research Laboratory
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- Yano Junko
- Fukujuji Hospital, Japan Anti-Tuberculosis Association
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- Ito Kunihiko
- Fukujuji Hospital, Japan Anti-Tuberculosis Association
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- Sugita Hironobu
- Fukujuji Hospital, Japan Anti-Tuberculosis Association
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- Mizutani Seiji
- Fukujuji Hospital, Japan Anti-Tuberculosis Association
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- Ogata Hideo
- Fukujuji Hospital, Japan Anti-Tuberculosis Association
Bibliographic Information
- Other Title
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- TBGLによる肺結核症の血清診断
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Abstract
Enzyme-linked immunosorbent assay (ELISA) was used to examine serum antibody levels of mycobacterial antigen in 92 patients with active tuberculosis, 36 with cured tuberculosis, 45 with nontuberculous mycobacteriosis, and as 31 with other diseases. Glycolipid fraction containing mainly cord factor (trehalose-6, 6′-mycolate) from Mycobacterium tuberculosis H37Rv were used as ELISA antigen. Overall positive rates of the ELISA tests in the patients with active pulmonary tuberculosis, those with nontuberculous mycobacteriosis, and those with other diseases were 67.4%, 75.6%, and 6.5%, respectively. Patients with tuberculosis and those with nontuberculous mycobacteriosis differed from the control group (p<0.0001). Higher positive rates were correlated with bacterial loads (smear-positive vs smear-negative, p<0.01) and with chest roenrgenographic findings (far advanced or other cavitary vs noncavitary, p<0.01). Because 18 of 36 smear-negative patients (50%) had positive results, we believe that the ELISA test with this antigen can be useful for diagnosis of M. tuberculosis, especially in patients with smear-negative.
Journal
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- The Japanese journal of thoracic diseases
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The Japanese journal of thoracic diseases 35 (1), 43-48, 1997
The Japanese Respiratory Society
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Details
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- CRID
- 1390001205018061184
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- NII Article ID
- 130003679388
- 10008112158
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- NII Book ID
- AN00187758
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- ISSN
- 1883471X
- 03011542
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- PubMed
- 9071155
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- Text Lang
- ja
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- Data Source
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- JaLC
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed