パブロンゴールド^<【○!R】>による薬剤性肺炎の1例  [in Japanese] Drug-induced Pneumonitis Associated PABRON-GOLDR^<【○!R】>  [in Japanese]

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Abstract

症例は75歳男性, 以前より風邪症状があると市販の総合感冒薬 (パブロンS<sup>®</sup>) を常用していた. 入院6日前より風邪症状を認め, パブロンS<sup>®</sup>を内服していたが, なくなったので, 新しい総合感冒薬 (パブロンゴールド<sup>®</sup>)を内服した. その翌日より呼吸困難出現, 近医にて胸部レントゲン写真上, 両側にびまん性陰影を認めたため, 精査目的で当科に紹介された. 胸部CTでは両側に間質性陰影が認められた. 気管支肺胞洗浄液中には好中球, リンパ球などの炎症細胞が認められた. 経気管支肺生検では肥厚した肺胞壁や間質への単核球の浸潤が認められた. 末梢血のリンパ球を用いた薬剤リンパ球刺激試験ではパブロンゴールド<sup>®</sup>が陽性であった. 以上よりパブロンゴールド<sup>®</sup>による薬剤性肺炎と診断した. 入院後, ステロイドを投与したところ症状は速やかに改善したが陰影は遷延した.

A 75-year-old man had for many years taken the commercially sold medicine PABRON-S<sup>®</sup> whenever he caught a cold. He caught a cold and took the drug six days before admission. When PABRON-S<sup>®</sup> was not available, he took PABRON-GOLD<sup>®</sup> and experienced dyspnea the next day. A roentgenogram at another hospital revealed bilateral diffuse lung shadows. He was referred to our hospital. A thoracic CT scan showed bilateral interstitial shadows. Bronchoalveolar lavage fluid contained inflammatory cells including neutrophils and lymphocytes. Examination of a transbronchial lung biopsy specimen showed infiltration of mononuclear cells into the thick alveolar wall and interstitum. A drug lymphocyte stimulation test with PABRON-GOLD<sup>®</sup> was positive. Based on these findings, we believe that this patient had drug-induced pneumonitis caused by PABRON-GOLD<sup>®</sup>. He was treated with a steroid hormone and his symptoms resolved immediately, the abnormal roentgenographic shadows remained longer.

Journal

  • The Japanese journal of thoracic diseases

    The Japanese journal of thoracic diseases 35(1), 72-76, 1997-01-25

    The Japanese Respiratory Society

References:  16

Cited by:  5

Codes

  • NII Article ID (NAID)
    10008112238
  • NII NACSIS-CAT ID (NCID)
    AN00187758
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03011542
  • Data Source
    CJP  CJPref  J-STAGE 
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