第17回 日本心電学会サテライト国際シンポジウム

• Inoue Hiroshi

  The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University

• Nagasawa Hidehiko

  The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University

• Fujiki Akira

  The Second Department of Internal Medicine, Toyama Medical and Pharmaceutical University

• Fujikura Naoki

  Shiraoka Research Station of Biological Science, Nissan Chemical Industries

書誌事項

タイトル別名

• Oita International Electrocardiology Symposium 2000 “Electrophysiology and Management of Lethal Arrhythmias in the New Millennium: From Genes to Bedside”
• Effects of a new antiarrhythmic drug, NIP-142, on atrial flutter in the dog

抄録

A new benzopyran derivative, NIP-142, blocks IK_ACh and is effective in suppressing vagallyinduced atrial fibrillation in the dog. We studied effects of NIP-142 on atrial flutter in the dog. In 6 dogs, atrial flutter due to reentry was induced after placing the intercaval obstacle. NIP-142 (3 mg/kg) terminated atrial flutter in all 6 dogs without changes in atrial flutter cycle length and prevented reinitiation of atrial flutter. NIP-142 prolonged atrial refractoriness at faster basic cycle length without changes in conduction time. These results indicate that the efficacy of NIP-142 on atrial flutter is probably due to class III antiarrhythmic effect different from selective l Kr blockers.

収録刊行物

• 心電図

  心電図 20 (Suppl3), 55-56, 2000

  一般社団法人　日本不整脈心電学会

詳細情報

• CRID: 1390001204772094976
• NII論文ID: 10008113993
• NII論文ID: 130004087472
• NII書誌ID: AN00358282
• DOI: 10.5105/jse.20.suppl3_55
• ISSN: 18842437
• ISSN: 02851660
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可