P450などの薬物代謝酵素にみられるポリモルフィズムと今後の薬物処方 Genetic polymorphism of drug metabolizing enzymes and their role in individual drug therapy.:Genetic polymorphism of drug metabolizing enzymes and their role in individual drug therapy

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著者

    • 山添 康 YAMAZOE Yasushi
    • 東北大学大学院薬学研究科薬物動態学分野 Department of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
    • 永田 清 NAGATA Kiyoshi
    • 東北大学大学院薬学研究科薬物動態学分野 Department of Drug Metabolism and Molecular Toxicology,Graduate School of Pharmaceutical Sciences, Tohoku University

抄録

Genetic polymorphism of drug metabolizing enzymes such as cytochrome P450 influences individual drug efficacy and safy through the alteration of pharmacokinetics and disposition of drugs. Considerable amounts of data are now accumulated for allelic differences of various enzymes. Here, current understanding of genotype information is summarized for their use on individual optimization of drug therapy.

収録刊行物

  • Drug delivery system

    Drug delivery system 17(2), 103-112, 2002-03-10

    日本DDS学会

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各種コード

  • NII論文ID(NAID)
    10008132183
  • NII書誌ID(NCID)
    AN10084591
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    09135006
  • データ提供元
    CJP書誌  J-STAGE 
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