P450などの薬物代謝酵素にみられるポリモルフィズムと今後の薬物処方  [in Japanese] Genetic polymorphism of drug metabolizing enzymes and their role in individual drug therapy.:Genetic polymorphism of drug metabolizing enzymes and their role in individual drug therapy  [in Japanese]

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Author(s)

    • 山添 康 YAMAZOE Yasushi
    • 東北大学大学院薬学研究科薬物動態学分野 Department of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
    • 永田 清 NAGATA Kiyoshi
    • 東北大学大学院薬学研究科薬物動態学分野 Department of Drug Metabolism and Molecular Toxicology,Graduate School of Pharmaceutical Sciences, Tohoku University

Abstract

Genetic polymorphism of drug metabolizing enzymes such as cytochrome P450 influences individual drug efficacy and safy through the alteration of pharmacokinetics and disposition of drugs. Considerable amounts of data are now accumulated for allelic differences of various enzymes. Here, current understanding of genotype information is summarized for their use on individual optimization of drug therapy.

Journal

  • Drug Delivery System

    Drug Delivery System 17(2), 103-112, 2002-03-10

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

References:  16

Codes

  • NII Article ID (NAID)
    10008132183
  • NII NACSIS-CAT ID (NCID)
    AN10084591
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    09135006
  • Data Source
    CJP  J-STAGE 
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