舌癌の発生・進展における機械的刺激の影響に関する研究  [in Japanese] A Study on Effect of Mechanical Irritation in Development and Progression of Tongue Cancer  [in Japanese]

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Author(s)

    • 佐藤 孝幸 SATO Takayuki
    • 東京医科歯科大学歯学部生体機能制御歯科学系顎顔面外科学講座 Department of Maxillofacial Surgery, Life Science of Maxillofacial Systems, Faculty of Dentistry, Tokyo Medical and Dental University

Abstract

It is considered that the mechanical irritation acts as an inducer in the canceration process of tongue cancer.<BR>The purpose of this study was to clarify the effect of mechanical irritation on the development and progression of tongue cancer.<BR>Leukoplakia and cancer were produced on the hamster tongue by paratripsis and applying 1% DMBA acetone solution 3 times per week for 8 or 10 weeks, and there after only paratripsis was continued. The effect of mechanical irritation was examined histopathologically.<BR>The intensity of DNA damage caused by mechanical irritation was investigated by measuring the activity of Poly (ADP-ribose) polymerase (PADPRP), which is an enzyme associated with DNA damage.<BR>After carcinogenic treatment, canceration of leukoplakia and early carcinoma progressed into become advanced carcinoma histopathologically by mechanical irritation only. In the precancerous condition, active oxygen was found in part of the subepitherial inflamatory cell infiltration and in part of the cancer cells of carcinoma.<BR>The activity of PADPRP increased during the scratching period.<BR>These results suggest that the mechanical irritation acts accelatively in canceration and progression of tongue cancer and causes DNA damage.

Journal

  • THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN

    THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN 62(4), 532-550, 1995-12-31

    The Stomatological society, Japan

References:  90

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008139706
  • NII NACSIS-CAT ID (NCID)
    AN00302674
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03009149
  • Data Source
    CJP  CJPref  J-STAGE 
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