Application of Silver-Inorganic Antimicrobial Reagent for Dental Materials. Antimicrobial Action for Streptococcus mutans.

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  • Tanaka Takaaki
    Department of Crown and Bridge Prosthodontics, Nihon University School of Dentistry at Matsudo
  • Mizukawa Kazuhiro
    Department of Crown and Bridge Prosthodontics, Nihon University School of Dentistry at Matsudo
  • Shida Kouichirou
    Department of Crown and Bridge Prosthodontics, Nihon University School of Dentistry at Matsudo
  • Kobayashi Taira
    Department of Crown and Bridge Prosthodontics, Nihon University School of Dentistry at Matsudo
  • Mega Junichi
    Department of Dentistry for the Handicapped, Nihon University School of Dentistry at Matsudo

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Other Title
  • 銀糸無機抗菌剤の歯科材料への応用　　Ｓｔｒｅｐｔｏｃｏｃｃｕｓ　ｍｕｔａｎｓに対する抗菌作用
  • Antimicrobial Action for Streptococcus mutans
  • Streptococcus mutans に対する抗菌作用

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Abstract

Recently, the concept of hygiene has been promoted, and many sanitary goods that contain antimicrobial reagents have been produced. Such reagents are divided into organic and inorganic ones. Some literature has pointed out that these reagents have many disadvantages, such as short-time durability of antibacterial effect, degeneration by heating operation, and physical irritation. Furthermore, the organic antimicrobial reagents have intensive antimicrobial action, but long use of these reagents may cause microbial substitution and teratogenicity.<BR>We aimed to put inorganic antimicrobial reagent into practical use, and the effects of silver-inorganic antimicrobial reagents (IONPURETM and NOVARON AG 300TM) on oral microorganisms were examined.<BR>1. Minimum inhibitory concentrations (MICs) of antimicrobial reagents (IONPURE and NOVARON) for Streptococcus mutans were 7.5 mg/m/ and 1.3 mg/m/. The antimicrobial action was bacteriostatic. The microorganisms on resin plates that contained both antimicrobial reagents were remarkably reduced.<BR>2. MICs for Streptococcus mutans on resin plates that contained antimicrobial reagents were 5 wt%(IONPURE) and 10 wt%(NOVARON).<BR>3. Insoluble glucan synthesis was inhibited on NOVARON-containing resin plates. On the other hand, IONPURE was not so noticeable.<BR>4. The surviving microorganisms of Streptococcus mutans on resin plates that contained both antimicrobial reagents (3 wt%) were remarkably decreased.<BR>These results suggest that IONPURE and NOVARON were effectual antimicrobial reagents against Streptococcus mutans, and that they were useful for antimicrobial prosthesis.

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