アパタイト複合コラーゲン材を用いた骨形成に関する実験的研究  [in Japanese] Experimental Studies on Bone Formation with Apatite-Collagen Material  [in Japanese]

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Author(s)

    • 北山 展弘 KITAYAMA Nobuhiro
    • 大阪歯科大学大学院歯学研究科歯科補綴学専攻 Graduate School of Dentistry (Prosthodontics) , Osaka Dental University

Abstract

This experimental study was performed to investigate bone tissue reaction of apatite-collagen conjugated sponge in the healing process of bone. The research was done on bone formation in relation to microvascular construction using scanning electron microscope.<BR>Octacalcium phosphate (OCP)-collagen conjugated sponge was employed as experimental material, having hydration activity, together with type I collagen gel in a short time under physiological conditions. Japanese monkeys were employed as experimental animals.<BR>Bilateral lower premolars and molars were extracted. After healing of the site, an artificial bone defect was made, and the material was inserted. These animals were sacrificed 2, 3, 4 and 8 weeks after operation. Acryl plastic was injected via the common carotid arteries utilizing the plastic injection method to prepare a microcast around the experimental region. The injected materials were coated with gold in order to use scanning electron microscopy.<BR>In the first two weeks, this OCP-collagen sponge guided a dense capillary network and new bone formation was observed around OCP particles with osteoblasts in the experimental region. And it promoted osseous healing of the sight.<BR>Application of sponge in an alveolar bone defect promotes bone formation in preparation for prosthodontic treatment.

Journal

  • Nihon Hotetsu Shika Gakkai Zasshi

    Nihon Hotetsu Shika Gakkai Zasshi 41(1), 86-93, 1997-02-01

    Japan Prosthodontic Society

References:  25

Cited by:  6

Codes

  • NII Article ID (NAID)
    10008165357
  • NII NACSIS-CAT ID (NCID)
    AN00197911
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03895386
  • Data Source
    CJP  CJPref  J-STAGE 
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