高分子電解質錯体の補綴領域への応用 : 高分子電解質錯体とハイドロキシアパタイト顆粒のハイブリッド体の基礎的研究  [in Japanese] Prosthodontics Application of Polyelectrolyte Complex : Basic Study of Hybrid Biomaterial with Polyelectrolyte Complex and Hydroxyapatite Granules  [in Japanese]

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Author(s)

    • 田口 健一 TAGUCHI Kenichi
    • 昭和大学歯学部第三歯科補綴学教室 The Third Department of Prosthodontics, Showa University School of Dentistry

Abstract

The purpose of this study was to investigate whether polyelectrolyte complexes (PECs) could be applied as new biomaterials for jaw reconstruction and bone tissue filling. Among the 90 different PEC combinations available, 32 could be confirmed to exist as gels in solvents with the naked eye, and five of these could be removed from the solvent without losing their shape. The best of these five, 6 X and <I>x</I>-carrageenan were selected, and spherical PEC (PEC ball) were prepared. Their shapes and sizes could be adjusted at will. By mixing these PECs with Hydroxyapatite (HAP) granules, it was possible to produce HAPEC balls. Then these were implanted in rats. Since their shape changed in the subcutaneous tissue, no injurious effects could be detected. HAPEC ball had not broken down 24 weeks later, and no breaking apart, dispersion, etc. of HAP granules was observed. In bone tissue, both PEC ball and HAPEC ball were absorbed and replaced by bone. The findings showed that both PEC ball and HAPEC ball are biocompatible and bioabsorbable. Since PEC also has very high osteoconduction, it appears to be a substance that can be expected to perform well as a biomaterial for reconstructing bone tissue.

Journal

  • Nihon Hotetsu Shika Gakkai Zasshi

    Nihon Hotetsu Shika Gakkai Zasshi 41(4), 645-656, 1997-08-01

    Japan Prosthodontic Society

References:  33

Cited by:  10

Codes

  • NII Article ID (NAID)
    10008167176
  • NII NACSIS-CAT ID (NCID)
    AN00197911
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03895386
  • Data Source
    CJP  CJPref  J-STAGE 
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