高分子電解質錯体の補綴領域への応用　高分子電解質錯体とハイドロキシアパタイトか粒のハイブリッド体の基礎的研究

DOI Web Site 被引用文献10件 参考文献33件

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タイトル別名
  • Prosthodontics Application of Polyelectrolyte Complex. Basic Study of Hybrid Biomaterial with Polyelectrolyte Complex and Hydroxyapatite Granules.
  • Basic Study of Hybrid Biomaterial with Polyelectrolyte Complex and Hydroxyapatite Granules
  • 高分子電解質錯体とハイドロキシアパタイト顆粒のハイブリッド体の基礎的研究

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The purpose of this study was to investigate whether polyelectrolyte complexes (PECs) could be applied as new biomaterials for jaw reconstruction and bone tissue filling. Among the 90 different PEC combinations available, 32 could be confirmed to exist as gels in solvents with the naked eye, and five of these could be removed from the solvent without losing their shape. The best of these five, 6 X and x-carrageenan were selected, and spherical PEC (PEC ball) were prepared. Their shapes and sizes could be adjusted at will. By mixing these PECs with Hydroxyapatite (HAP) granules, it was possible to produce HAPEC balls. Then these were implanted in rats. Since their shape changed in the subcutaneous tissue, no injurious effects could be detected. HAPEC ball had not broken down 24 weeks later, and no breaking apart, dispersion, etc. of HAP granules was observed. In bone tissue, both PEC ball and HAPEC ball were absorbed and replaced by bone. The findings showed that both PEC ball and HAPEC ball are biocompatible and bioabsorbable. Since PEC also has very high osteoconduction, it appears to be a substance that can be expected to perform well as a biomaterial for reconstructing bone tissue.

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