生体材料の性質の違いが骨芽細胞の活性に与える影響 : 細胞内遊離カルシウムの変化について  [in Japanese] The Effect of Biomaterials on the Activities of Osteoblasts : Alterations of Intracellular Free Calcium  [in Japanese]

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Author(s)

    • 塩路 浩也 SHIOJI Hiroya
    • 岩手医科大学歯学部歯科補綴学第二講座 Department of Fixed Prosthodontics,School of Dentistry, Iwate Medical University

Abstract

The purpose of this study was to clarify how different components of biomaterials affect cell activities of osteoblasts. In this experiment, osteoblasts were cultured on titanium and bioactive glass, and the intracellular free calcium ([Ca<SUP>2+</SUP>] <SUB>1</SUB>) that plays an important role in the intracellular signalling system was measured. In the early stages of the culture, the osteoblaststended to increase [Ca<SUP>2+</SUP>], when cultured on bioactive glass more than on titanium. This indicated that direct contact of osteoblasts to bioactive glass was essential to generate theobserved effect on [Ca<SUP>2+</SUP>] <SUB>1</SUB>. Furthermore, elevation of [Ca<SUP>2+</SUP>] <SUB>1</SUB> did not occur whenextracellular calcium was supplied. These results suggested that bioactive glassaffects the intracellular signalling system of the osteoblasts when in contact with bioactive glass

Journal

  • Nihon Hotetsu Shika Gakkai Zasshi

    Nihon Hotetsu Shika Gakkai Zasshi 42(1), 84-89, 1998-02-01

    Japan Prosthodontic Society

References:  35

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008168524
  • NII NACSIS-CAT ID (NCID)
    AN00197911
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03895386
  • Data Source
    CJP  CJPref  J-STAGE 
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