形成可能な骨充填材としてのリン酸4カルシウム・リン酸カルシウム2水和物・クエン酸硬化体の研究 : 骨内埋入時の組織反応  [in Japanese] A Study of Hardening Material as a Bone Graft Cement Which Has a Plasticity Property, Consisting of Tetracalcium Phosphate, Dicalcium Phosphate Dihydrate and Citric Acid : Histological Response in the Bone Implantation  [in Japanese]

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Abstract

The purpose of this study was to investigate the histocompatibility of a bone graft cement, obtained by kneading an equimolar mixture of tetracalcium phosphate and dicalcium phosphate dihydrate with 35% citric acid solution (containing 0.5% gelatin, P/L 2.0; Te/DCPD). High-density hydroxyapatite granules (HAP, particle size: 300-500 μm) were used as a control.<BR>Three holes, 5 mm in depth and 5 mm in diameter, were drilled at 10 mm intervals on the corpus of the tibia of mature beagles. Te/DCPD was shaped into a cylinder (5mm in height and 5 mm in diameter), and implanted into one hole. HAP was implanted into the 2nd hole, and the 3rd one was used as a sham operation. The implants were removed at 2, 12, and 24 weeks after implantation, and then all specimens regardless of decalcification were processed for routine microscopic examination. The results were as follows:<BR>At 2 weeks, Te/DCPD and HAP did not induce an inflammatory reaction in periphery bone marrow tissue, and Te/DCPD was in direct contacted with new bone tissue. At 24 weeks, Te/DCPD was absorbed peripherally, and new bone tissue had replaced the absorbed portion.<BR>It was concluded that Te/DCPD may be useful as a bone graft cement as well as HAP, because it was biodegradable and replaced gently by new bone tissue.

Journal

  • Nihon Hotetsu Shika Gakkai Zasshi

    Nihon Hotetsu Shika Gakkai Zasshi 42(3), 409-414, 1998-06-10

    Japan Prosthodontic Society

References:  17

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008169663
  • NII NACSIS-CAT ID (NCID)
    AN00197911
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03895386
  • Data Source
    CJP  CJPref  J-STAGE 
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