高分子電解質錯体とハイドロキシアパタイトとのハイブリッド体を用いた顎骨の再構築  [in Japanese] Reconstruction of the Jaw with a Hybrid Substance Consisting of Polyelectrolyte Complex (PEC) and Hydroxyapatite  [in Japanese]

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Author(s)

    • 飯田 克実 IIDA Katsumi
    • 昭和大学歯学部第三歯科補綴学教室 The Third Department of Prosthodontics, Showa University School of Dentistry

Abstract

In this study, to reconstruct the jaw defect site, a hybrid substance consistingof Polyelectrolyte Complex (PEC) and Hydroxyapatite (HA) was prepared, and a prosthesis with this substance was fabricated in the mandible of adult dogs. Two types of HA with 500 μm or 1, 000 μm in particle diameter and a pore rate of 35% or more were used. The animals consisted of 12 male Beagles. As for PEC, polycation (S-110) and polyanion (S-chitin 140), which show favorable cellular adhesiveness and cell proliferation, were used. The rate and amount of bone formation in the PEC-HA Hybrid group were significantly higher than those in the controlgroup, the PEC group and the granule group.<BR>The results suggested that PEC-HAHybrid can be clinically used as a biomaterial that may shorten the period required for bone formation and increase the amount of neogenetic bone.

Journal

  • Nihon Hotetsu Shika Gakkai Zasshi

    Nihon Hotetsu Shika Gakkai Zasshi 43(6), 1034-1042, 1999-12-10

    Japan Prosthodontic Society

References:  82

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008175139
  • NII NACSIS-CAT ID (NCID)
    AN00197911
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03895386
  • Data Source
    CJP  CJPref  J-STAGE 
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