Molecular Pathopharmacology of Cellular Responses to Brain Ischemia. The involvement of cytokines, chemokines and inducible nitric oxide synthase (iNOS) induced by a transient ischemia in neuronal survival/death in rat brain.

• OKUMA Yasunobu

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University

• UEHARA Takashi

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University

• MIYAZAKI Hiroyuki

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University

• MIYASAKA Tomohiro

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University

• NOMURA Yasuyuki

  Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University

Bibliographic Information

Other Title

• 脳虚血への細胞応答の病態分子薬理　　脳虚血へのグリア細胞のサイトカイン，ケモカイン，ｉＮＯＳ誘導応答とニューロン死
• ノウ キョケツ エ ノ グリア サイボウ ノ サイトカイン ケモカイン iNO
• 脳虚血への細胞応答の病態分子薬理

Abstract

Inflammatory/immunological processes underlie the survival/damage of neurons after brain ischemia. In glial cells, cytokines such as IL-1β and TNF-α are produced following ischemic stresses. On the other hand, it is suggested that NO/iNOS is involved in neuronal apoptosis. We here review the ischemia-induced production of cytokine/iNOS and the neurotrophic/neurotoxic effects. It is not clear whether or not the neuronal death after brain ischemia is apoptosis or necrosis. Under the condition of transient forebrain ischemia, however, we obtained results suggesting apoptosis in the delayed neuronal death of the CA1 pyramidal neurons. The time course and cellular localization of postischemic iNOS expression depend on the properties of the ischemic insult. The iNOS induction is detected primarily in astrocytes after the transient forebrain ischemia when the neuronal apoptosis is observed. We discuss a variety of cytokines with neurotrophic/neurotoxic actions that are produced by ischemia or environmental stresses in glial cells. From the neurotoxicological aspect of the neuro-glial interaction, we also review recent findings on signaling pathways of the iNOS induction in glial cells and the mechanisms of the cytotoxic actions of NO.

Journal

• Folia Pharmacologica Japonica

  Folia Pharmacologica Japonica 111 (1), 37-44, 1998

  The Japanese Pharmacological Society

Keywords

• brain ischemia
• neuronal apoptosis
• iNOS
• glial cells
• cytokine

Details

• CRID: 1390282679250282496
• NII Article ID: 30034987259
• NII Article ID: 10008182021
• NII Book ID: AN00198335
• DOI: 10.1254/fpj.111.37
• COI: 1:CAS:528:DyaK1cXjs1egtg%3D%3D
• ISSN: 13478397
• ISSN: 00155691
• NDL BIB ID: 4382496
• PubMed: 9551471
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4382496
• Web Site: https://search.jamas.or.jp/link/ui/1998103603
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed