Dopamine D4 Receptors.

• M. Helmeste Daiga

  Department of Psychiatry,University of California,Irvine,North Campus Zot 1681,Irvine,California 92697-1681,USA

• Wa Tang Siu

  Department of Psychiatry,University of California,Irvine,North Campus Zot 1681,Irvine,California 92697-1681,USA

Abstract

Initial investigations on dopamine D₄ receptors generated much interest in the role of this receptor in schizophrenia and other aspects of human behavior, as well as new opportunities for novel therapeutics.However, attempts to treat patients suffering from schizophrenia with dopamine D₄ agents have failed to yield satisfactory results so far.An examination of the dopamine D₄ literature shows that contrasting and conflicting data seemed to be the norm in this field of research.This paper reviews the literature on the dopamine D₄ receptor and discusses many of the associated methodological problems that might have contributed to the paradoxical findings.

Journal

• The Japanese Journal of Pharmacology

  The Japanese Journal of Pharmacology 82 (1), 1-14, 2000

  The Japanese Pharmacological Society

Keywords

• Dopamine receptor
• D<SUB>4</SUB>
• Schizophrenia
• Antipsychotic drug
• Receptor polymorphism

Details

• CRID: 1390282679263997824
• NII Article ID: 10008182407
• NII Book ID: AA00691188
• DOI: 10.1254/jjp.82.1
• COI: 1:CAS:528:DC%2BD3cXotF2ksg%3D%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL BIB ID: 4966403
• PubMed: 10874582
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4966403
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819307218?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819307218?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/82/1/82_1_1/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000149125
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed