Dopamine D4 Receptors.

• M. Helmeste Daiga

  Department of Psychiatry,University of California,Irvine,North Campus Zot 1681,Irvine,California 92697-1681,USA

• Wa Tang Siu

  Department of Psychiatry,University of California,Irvine,North Campus Zot 1681,Irvine,California 92697-1681,USA

抄録

Initial investigations on dopamine D₄ receptors generated much interest in the role of this receptor in schizophrenia and other aspects of human behavior, as well as new opportunities for novel therapeutics.However, attempts to treat patients suffering from schizophrenia with dopamine D₄ agents have failed to yield satisfactory results so far.An examination of the dopamine D₄ literature shows that contrasting and conflicting data seemed to be the norm in this field of research.This paper reviews the literature on the dopamine D₄ receptor and discusses many of the associated methodological problems that might have contributed to the paradoxical findings.

収録刊行物

• Jpn.J.Pharmacol.

  Jpn.J.Pharmacol. 82 (1), 1-14, 2000

  公益社団法人 日本薬理学会

キーワード

• Dopamine receptor
• D<SUB>4</SUB>
• Schizophrenia
• Antipsychotic drug
• Receptor polymorphism

詳細情報

• CRID: 1390282679263997824
• NII論文ID: 10008182407
• NII書誌ID: AA00691188
• DOI: 10.1254/jjp.82.1
• COI: 1:CAS:528:DC%2BD3cXotF2ksg%3D%3D
• ISSN: 13473506
• ISSN: 00215198
• NDL書誌ID: 4966403
• PubMed: 10874582
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4966403
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819307218?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S0021519819307218?httpAccept=text/plain
• Web Site: https://www.jstage.jst.go.jp/article/jjp/82/1/82_1_1/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2000149125
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可