Molecular Basis of Spatio-temporal Dynamics in Inositol 1,4,5-Trisphosphate-Mediated Ca^<2+> Signalling

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Author(s)

Abstract

Inositol 1, 4, 5−trisphosphate(IP<SUB>3</SUB>)−mediated Ca<SUP>2+</SUP> signalling regulates many important cell functions, and the spatio−temporal dynamics of the Ca<SUP>2+</SUP> signalling is a crucial factor for its versatility.The molecular mechanisms that control Ca<SUP>2+</SUP> signalling are now being investigated, and I here describe the subtypes of IP<SUB>3</SUB> receptors that have distinct functional properties and contribute to the diversity of Ca<SUP>2+</SUP> signalling patterns.I also discuss the spatio−temporal dynamics of intracellular IP<SUB>3</SUB> concentration, describing recent methodological advances in monitoring intracellular IP<SUB>3</SUB> concentration.These findings highlight the potential importance of the spatio−temporal information of any signalling molecule.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 82(1), 15-20, 2000-01-01

    The Japanese Pharmacological Society

References:  41

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008182507
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4966407
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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