Anti-type I Allergic Mechanisms of Mao-bushi-saishin-to in Mice

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Author(s)

Abstract

We investigated the anti−allergic effect of mao−bushi−saishin−to(MBS)on the type I allergy model in mice.When MBS was administered orally at a dose of 0.5 or 1.0g/kg, edema of the footpad, the amount of plasma IgE and the ratio of eosinophilic leukocytes in peritoneal exudate cells were all dose−relatedly suppressed.Moreover to investigate the anti−type I allergic mechanisms of MBS, enzyme−linked immunosorbent assay was performed to determine the interleukin(IL)−4, IL−5 and interferon(IFN)−gamma production from splenocytes that were stimulated by pokeweed mitogen for 48 h.In addition, we assayed IgE production from splenic B cells stimulated with the lipopolysaccharide and IL−4 for 7 days.MBS inhibited the IL−4 and IFN−gamma production, but IL−5 and IgE production were not affected.Thus possibly, the inhibition of IL−4 production may partially be involved in the expression of the anti−type I allergic effects of MBS.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 82(1), 29-33, 2000-01-01

    The Japanese Pharmacological Society

References:  22

Cited by:  3

Codes

  • NII Article ID (NAID)
    10008182578
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4966426
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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