Effects of Neuropeptide Y on Double-Peaked Constrictor Responses to Periarterial Nerve Stimulation in Isolated, Perfused Canine Splenic Arteries

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Author(s)

Abstract

The periarterial electrical nerve stimulation readily induced a double−peaked vasoconstriction in the isolated, perfused canine splenic artery.P2X−Purinoceptors have previously been shown to be involved mainly in the 1st−phase response and α<SUB>1</SUB>−adrenoceptors, mostly in the 2nd−one.The dose used of neuropeptide Y(NPY)(0.01−0.1μM)given into the preparation caused a slight but insignificant vasoconstriction.The treatment with NPY at concentrations of 0.01−0.1μM produced a parallel inhibition on the 1st− and 2nd−phase responses following nerve stimulation at the frequencies used(1−10 Hz)in a dose−dependent manner.The vasoconstrictor responses to administered ATP(0.01−1μmol)or noradrenaline(0.03−3 nmol)were slightly but not significantly potentiated by 0.1μM NPY.The results indicate that NPY predominantly exerts a prejunctionally inhibitory modulation on the purinergic and adrenergic transmission in peripheral sympathetic nerves innervating the canine splenic artery.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 82(1), 67-70, 2000-01-01

    The Japanese Pharmacological Society

References:  15

Cited by:  6

Codes

  • NII Article ID (NAID)
    10008182750
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4966488
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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