Effects of Neuropeptide Y on Double-Peaked Constrictor Responses to Periarterial Nerve Stimulation in Isolated, Perfused Canine Splenic Arteries.
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- Yang Xiao-Ping
- Department of Pharmacology,Shinshu University School of Medicine,Matsumoto 390-8621,Japan
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- Chiba Shigetoshi
- Department of Pharmacology,Shinshu University School of Medicine,Matsumoto 390-8621,Japan
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抄録
The periarterial electrical nerve stimulation readily induced a double−peaked vasoconstriction in the isolated, perfused canine splenic artery.P2X−Purinoceptors have previously been shown to be involved mainly in the 1st−phase response and α1−adrenoceptors, mostly in the 2nd−one.The dose used of neuropeptide Y(NPY)(0.01−0.1μM)given into the preparation caused a slight but insignificant vasoconstriction.The treatment with NPY at concentrations of 0.01−0.1μM produced a parallel inhibition on the 1st− and 2nd−phase responses following nerve stimulation at the frequencies used(1−10 Hz)in a dose−dependent manner.The vasoconstrictor responses to administered ATP(0.01−1μmol)or noradrenaline(0.03−3 nmol)were slightly but not significantly potentiated by 0.1μM NPY.The results indicate that NPY predominantly exerts a prejunctionally inhibitory modulation on the purinergic and adrenergic transmission in peripheral sympathetic nerves innervating the canine splenic artery.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 82 (1), 67-70, 2000
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204287102080
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- NII論文ID
- 10008182750
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DC%2BD3cXotF2kuw%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4966488
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- PubMed
- 10874591
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4966488
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- https://api.elsevier.com/content/article/PII:S0021519819307309?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/82/1/82_1_67/_pdf
- https://search.jamas.or.jp/link/ui/2000141971
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