Perivascular Purinergic Nerve-Induced Vasoconstrictions in Canine Isolated Splenic Arteries

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抄録

We tried to induce selective perivascular purinergic nerve stimulation in isolated canine splenic arterial preparations, using the cannula insertion method.Under the conditions of periarterial electrical stimulation(ES), i.e., trains of 1, 3 and 10 pulses, 1−ms pulse duration and 10−V amplitude at 1 Hz, monophasic vasoconstriction was consistently induced.The ES−induced vasoconstriction was not influenced by prazosin in doses that completely inhibited noradrenaline−induced vasoconstrictions, but it was suppressed by α, β−methylene ATP, a P2X purinoceptor desensitizer.Thus, it is indicated that a selective purinergic transmitter release is readily obtained in the isolated splenic arterial preparation.

収録刊行物

  • The Japanese journal of pharmacology

    The Japanese journal of pharmacology 82(1), 71-73, 2000-01-01

    公益社団法人 日本薬理学会

参考文献:  12件中 1-12件 を表示

被引用文献:  2件中 1-2件 を表示

各種コード

  • NII論文ID(NAID)
    10008182766
  • NII書誌ID(NCID)
    AA00691188
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    00215198
  • NDL 記事登録ID
    4966497
  • NDL 雑誌分類
    ZS51(科学技術--薬学)
  • NDL 請求記号
    Z53-D199
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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