Phenytoin and Its Metabolite, 5-(4-Hydroxyphenyl)-5-Phenylhydantoin, Show Bone Resorption in Cultured Neonatal Mouse Calvaria

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Author(s)

Abstract

The effects of phenytoin and its major metabolite, 5−(4−hydroxyphenyl)−5−phenylhydantoin(HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro.Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture.This effect may be the cause of phenytoin−induced bone loss in vivo.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 82(1), 82-84, 2000-01-01

    The Japanese Pharmacological Society

References:  10

Cited by:  2

Codes

  • NII Article ID (NAID)
    10008182811
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    4966527
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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