Inhibitory Action of Troglitazone, an Insulin-Sensitizing Agent, on the Calcium Current in Cardiac Ventricular Cells of Guinea Pig

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Author(s)

Abstract

We investigated the effects of troglitazone, a new orally active hypoglycemic agent, on the voltage-dependent L-type Ca<SUP>2+</SUP> current in single cardiac ventricular myocytes of guinea pigs by the whole-cell voltage clamp technique.Troglitazone blocked the Ca<SUP>2+</SUP> currents in a concentration-dependent manner.The inhibitory effect was more potent at the holding potential(HP)of −50mV than at −80mV.The half-maximum inhibiting concentration(IC<SUB>50</SUB>)of troglitazone was 0.8μM with the Hill coefficient of 0.84 at −50mV HP.In contrast, the IC<SUB>50</SUB> value was higher than 10μM at −80mV HP.These results suggest that troglitazone at therapeutic concentrations inhibit the Ca<SUP>2+</SUP> channels and may exert cardioprotective effects in diabetic conditions.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 82(2), 102-109, 2000-02-01

    The Japanese Pharmacological Society

References:  30

Codes

  • NII Article ID (NAID)
    10008182980
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00215198
  • NDL Article ID
    5283877
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  NDL  J-STAGE 
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