Antinociception Induced by Amitriptyline and Imipramine Is Mediated by α_<2A>-Adrenoceptors

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Author(s)

Abstract

The involvement of α<SUB>2</SUB>-adrenoceptors in the antinociception induced by the tricyclic antidepressants amitriptyline and imipramine was investigated in mice by using the hot-plate and abdominal constriction tests.The antinociception produced by amitriptyline(15mg/kg, i.p.) and imipramine(15mg/kg, i.p.) was prevented by reserpine(2mg/kg, i.p.) and yohimbine(3-10mg/kg, i.p.) but not by naloxone(1mg/kg, i.p.), atropine(5mg/kg, i.p.), CGP 35348(100mg/kg, i.p.) and prazosin(1mg/kg, i.p.).On the basis of the above data, it can be postulated that amitriptyline and imipramine exerted their antinociceptive effect by activation of α<SUB>2</SUB>-adrenoceptors.Administration of the α<SUB>2A</SUB>-adrenoceptor antagonist BRL 44408(1mg/kg, i.p.) prevented amitriptyline and imipramine antinociception, whereas the α<SUB>2B/C</SUB>-adrenoceptor antagonist ARC 239(10mg/kg, i.p.) was ineffective.These data indicate that the enhancement of the pain threshold produced by amitriptyline and imipramine is mediated by activation of α<SUB>2A</SUB>-adrenoceptors.Neither tricyclic antidepressants nor the antagonists used impaired mouse performance evaluated by the rota-rod and hole-board tests.

Journal

  • The Japanese Journal of Pharmacology

    The Japanese Journal of Pharmacology 82(2), 130-137, 2000-02-01

    The Japanese Pharmacological Society

References:  42

Cited by:  1

Codes

  • NII Article ID (NAID)
    10008183091
  • NII NACSIS-CAT ID (NCID)
    AA00691188
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    00215198
  • NDL Article ID
    5283935
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-D199
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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